纯度:>98% by TLC;NMR (Conforms)
分子式:C30H40Cl2N4
分子量:527.58
溶剂:DMSO (1 mg/ml) Water (1 mg/ml)
性状:Beige solid
存储:RT
Activity (short version):Mitochondrial import inhibitor
Function / Pharmacology:Attenuates mitochondrial protein import (4-10 uM). Discovered in a screen of FDA-approved drugs. Blocks translocation of a mutant form of alanine: glyoxylate aminotransferase (AGT) to the mitochondria and restores AGT trafficking to peroxisomes.1 Also reduces oxalate accumulation and thus has potential to treat patients with primary hyperoxaluria 1 who possess mutations in AGT.1 Also displays antimicrobial activity2, inhibits apamin-sensitive K+ channels3 and induces apoptosis by inhibiting XIAP4.