纯度:98% by HPLC;NMR (Conforms)
分子式:C16H18NO2S
分子量:307.37
溶剂:DMSO (80 mg/ml) Ethanol (80 mg/ml)
性状:Brown waxy solid
存储:-20°C
Activity (short version):GPR40 antagonist
Function / Pharmacology:A GPR40 receptor antagonist1. Suppresses fatty acid-induced elevation of intracellular Ca++. Inhibits palmitic acid potentiated glucose–stimulated insulin secretion in Min6 pancreatic β cells in vitro. Lowers serum insulin levels, increases insulin sensitivity2 in obese Zucker rats (6 mg/kg)2. Reduces pancreatic β cell apoptosis in obese diabetic (db/db) rats3. Protects Min6 β cells from palmitic acid-induced ER stress and apoptosis4