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Heclin
  • 英文名称:Heclin
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10400
  • cas:890605-54-6
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10400
用途 科研检测
英文名称 Heclin
包装规格 1MG
CAS编号 890605-54-6
别名 Heclin
纯度 98+%
分子式
是否进口
纯度:98% by TLC,;NMR (Conforms)
分子式:C17H17NO3
分子量:283.33
溶剂:DMSO (40 mg/ml) Ethanol (10 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):HECT domain containing E3 ubiquitin ligase inhibitor
Function / Pharmacology:The first small molecule inhibitor of the HECT domain-containing E3 ubiquitin ligases. Heclin (HECT ligase inhibitor) inhibits several HECT ligases in cultured cells, IC50s = 6.8, 6.3 and 6.9 ?M for Smurf2, Nedd4 and WWP1 respectively. It does not block E2 binding but causes a conformational change which results in oxidation of the active site cysteine. Cells tolerate heclin treatment for several hours but exposure for 24 hours leads to death in HEK293 cells, consistent with an essential role for HECT ligase activity in mammalian cells. Heclin does not inhibit RING domain ligases.1 Thus it is a valuable tool for distinguishing between RING and HECT-mediated ubiquitination. Prevents proteasomal degradation of thioredoxin-interacting protein after microbial infection with subsequent reduction of pro-inflammatory mediators.2 Improves short-term memory, consolidation, retrieval and reconsolidation of contextual fear in rodent models.3
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