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L524-0366
- 英文名称：L524-0366
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10402
- cas：951612-19-4
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10402 |
| 用途 | 科研检测 |
| 英文名称 | L524-0366 |
| 包装规格 | 1MG |
| CAS编号 | 951612-19-4 |
| 别名 | L524-0366 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C13H13ClN4OS
分子量:308.79
溶剂:DMSO (14 mg/ml) Ethanol (2 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Fn14 antagonist
Function / Pharmacology:Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 μM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. It completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM1. L524-0366 is the first compound known to interfere with the TWEAK/Fn14 inter-action and may serve as a lead compound for the development of new therapeutics2.
分子式:C13H13ClN4OS
分子量:308.79
溶剂:DMSO (14 mg/ml) Ethanol (2 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Fn14 antagonist
Function / Pharmacology:Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 μM). It specifically inhibits TWEAK-Fn14-mediated NFκB activation. It completely suppressed TWEAK-induced T98G cell migration (10 μM) without cytotoxicity up to 50 μM1. L524-0366 is the first compound known to interfere with the TWEAK/Fn14 inter-action and may serve as a lead compound for the development of new therapeutics2.
