纯度:98% by TLC,;NMR (Conforms)
分子式:C22H24Cl2N2O4
分子量:451.34
溶剂:DMSO (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Integrated stress response inhibitor
Function / Pharmacology:Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2β.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6