纯度:98% by TLC;NMR (Conforms)
分子式:C21H18F3NO3S2
分子量:453.50
溶剂:DMSO (40 mg/ml) Ethanol (20 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):PPARδ agonist
Function / Pharmacology:Potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1 Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves hematopoietic stem cell maintenance.2 Prevents downregulation of AMPK caused by a high-fat diet in liver and increases fatty acid oxidation.3 Upregulates human Sirt1 via Sp1 activation.4 Along with exercise, GW-501516 synergistically increases running endurance.5