纯度:98% by HPLC;NMR (Conforms)
分子式:C23H24N4O
分子量:372.46
溶剂:DMSO (50 mg/ml) Ethanol (14 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):p97 AAA ATPase inhibitor
Function / Pharmacology:Potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line1. It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway.1 ML241 and related inhibitors (DBeQ for example) have differential responses to p97 mutants as well as the presence of cofactors suggesting the possibility of context-dependent p97 inhibitors.2,3