纯度:98% by TLC,;NMR (Conforms)
分子式:C14H21BrN2O ? HCl
分子量:349.69
溶剂:DMSO (40 mg/ml) Water (50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Methyl-lysine binding protein inhibitor
Function / Pharmacology:The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1