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UNC-2170 HCl
- 英文名称:UNC-2170 HCl
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10412
- cas:1648707-58-7
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10412 |
用途 | 科研检测 |
英文名称 | UNC-2170 HCl |
包装规格 | 1MG |
CAS编号 | 1648707-58-7 |
别名 | UNC-2170 HCl |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C14H21BrN2O ? HCl
分子量:349.69
溶剂:DMSO (40 mg/ml) Water (50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Methyl-lysine binding protein inhibitor
Function / Pharmacology:The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
分子式:C14H21BrN2O ? HCl
分子量:349.69
溶剂:DMSO (40 mg/ml) Water (50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Methyl-lysine binding protein inhibitor
Function / Pharmacology:The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1