纯度:98% by TLC,;NMR (Conforms)
分子式:C23H24N6
分子量:384.48
溶剂:DMSO (40 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):USP1 - UAF1 inhibitor
Function / Pharmacology:Potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nm in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 ?M.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2 ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3