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ML323
- 英文名称:ML323
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10414
- cas:1572414-83-5
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10414 |
用途 | 科研检测 |
英文名称 | ML323 |
包装规格 | 1MG |
CAS编号 | 1572414-83-5 |
别名 | ML323 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C23H24N6
分子量:384.48
溶剂:DMSO (40 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):USP1 - UAF1 inhibitor
Function / Pharmacology:Potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nm in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 ?M.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2 ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3
分子式:C23H24N6
分子量:384.48
溶剂:DMSO (40 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):USP1 - UAF1 inhibitor
Function / Pharmacology:Potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nm in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 ?M.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2 ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3