纯度:98% by TLC;NMR (Conforms)
分子式:C18H21N3O2
分子量:311.38
溶剂:DMSO (30 mg/ml) Ethanol (8 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Estrogen-related receptor ERRβ and ERRγ agonist
Function / Pharmacology:Selective agonist at estrogen-related receptors ERR? and ERR? with minimal activity at ERR?, ER? and ER? at concentrations up to 30 μM.1 Displays antiproliferative activity in prostate cancer cells.2 Promotes hormone production and cell fusion in cytotrophoblasts.3 In breast cancer cells DY131 arrests cells in G2/M and causes mitotic spindle defects.4 Inhibits osteoclastogenesis and protects against inflammatory bone loss induced by LPS in vivo.5