纯度:98% by TLC;NMR (Conforms)
分子式:C18H17NO2
分子量:279.33
溶剂:DMSO (30 mg/ml) Ethanol (10 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):PHLP phosphatase inhibitor / Laminin inhibitor
Function / Pharmacology:A potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 ?M).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM IC50=19.35 ?M) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3