纯度:98% by TLC,;NMR (Conforms)
分子式:C14H14O4S2
分子量:310.39
溶剂:DMSO (15 mg/ml) Ethanol (1 mg/ml)
性状:Orange solid
存储:-20°C
Activity (short version):CtBP inhibitor; cdc25 phosphatase inhibitor
Function / Pharmacology:A potent and selective inhibitor of Cdc25 phosphatase (Ki = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.1 Induces cell cycle arrest, phosphorylation of EGFR and activation of ERK-1 and -2.2 Inhibits carboxyl-terminal binding protein a transcriptional corepressor that suppresses multiple pro-apoptotic and epithelial genes.3 Induces eryptosis in human erythrocytes.4