纯度:98% by TLC,;NMR (Conforms)
分子式:C23H20F3N5O2S
分子量:519.56
溶剂:DMSO (30 mg/ml) Ethanol (1 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):B-Raf mutant inhibitor
Function / Pharmacology:Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively).1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors. Endoplasmic reticulum stress and autophagy are induced in melanoma cells after treatment with dabrafenib and protect cells from dabrafenib toxicity.2 Induces epithelial differentiation in BRAF-mutant colorectal cancer cells.3