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4μ8C
- 英文名称:4μ8C
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10426
- cas:14003-96-4
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10426 |
用途 | 科研检测 |
英文名称 | 4μ8C |
包装规格 | 1MG |
CAS编号 | 14003-96-4 |
别名 | 4μ8C |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:97% by TLC;NMR (Conforms)
分子式:C11H8O4
分子量:204.18
溶剂:DMSO (20 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):IRE1 ribonuclease inhibitor
Function / Pharmacology:Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity1. Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells2. Blocks production of IL-4, IL-5 and IL-13 production in T cells3. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells4.
分子式:C11H8O4
分子量:204.18
溶剂:DMSO (20 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):IRE1 ribonuclease inhibitor
Function / Pharmacology:Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity1. Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells2. Blocks production of IL-4, IL-5 and IL-13 production in T cells3. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells4.