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4μ8C
- 英文名称：4μ8C
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10426
- cas：14003-96-4
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10426 |
| 用途 | 科研检测 |
| 英文名称 | 4μ8C |
| 包装规格 | 1MG |
| CAS编号 | 14003-96-4 |
| 别名 | 4μ8C |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:97% by TLC;NMR (Conforms)
分子式:C11H8O4
分子量:204.18
溶剂:DMSO (20 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):IRE1 ribonuclease inhibitor
Function / Pharmacology:Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity1. Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells2. Blocks production of IL-4, IL-5 and IL-13 production in T cells3. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells4.
分子式:C11H8O4
分子量:204.18
溶剂:DMSO (20 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):IRE1 ribonuclease inhibitor
Function / Pharmacology:Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity1. Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells2. Blocks production of IL-4, IL-5 and IL-13 production in T cells3. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells4.
