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CBR-5884
  • 英文名称:CBR-5884
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10433
  • cas:681159-27-3
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10433
用途 科研检测
英文名称 CBR-5884
包装规格 1MG
CAS编号 681159-27-3
别名 CBR-5884
纯度 98+%
分子式
是否进口
纯度:98% by TLC,;NMR (Conforms)
分子式:C14H12N2O4S2
分子量:336.39
溶剂:DMSO (50 mg/ml) DMF (50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):PHGDH / serine biosynthesis inhibitor
Function / Pharmacology:Potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM1. The action of PHGDH is the first committed step of serine biosynthesis2 and certain cancer cells overexpress PHGDH3. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents1.
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