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CBR-5884
- 英文名称:CBR-5884
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10433
- cas:681159-27-3
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10433 |
用途 | 科研检测 |
英文名称 | CBR-5884 |
包装规格 | 1MG |
CAS编号 | 681159-27-3 |
别名 | CBR-5884 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C14H12N2O4S2
分子量:336.39
溶剂:DMSO (50 mg/ml) DMF (50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):PHGDH / serine biosynthesis inhibitor
Function / Pharmacology:Potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM1. The action of PHGDH is the first committed step of serine biosynthesis2 and certain cancer cells overexpress PHGDH3. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents1.
分子式:C14H12N2O4S2
分子量:336.39
溶剂:DMSO (50 mg/ml) DMF (50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):PHGDH / serine biosynthesis inhibitor
Function / Pharmacology:Potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM1. The action of PHGDH is the first committed step of serine biosynthesis2 and certain cancer cells overexpress PHGDH3. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents1.