纯度:95% by HPLC,;NMR (Conforms)
分子式:C46H69N7O15
分子量:960.10
溶剂:DMSO (10 mg/ml)
性状:White or off-white lyophilize solid
存储:-20°C
Activity (short version):Gq inhibitor
Function / Pharmacology:YM-254890 is a novel Gαq/11 inhibitor,1 U46619-induced platelet aggregation is inhibited but phorbol ester- or ionophore-induced aggregation is not2 (IC50 = 0.1-0.2 μM)1. It blocks Pasteurella multocida toxin-mediated activation of Gαq.3 A highly useful new tool for studying Gαq/11-coupled receptor signaling and resulting cellular events.4