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PBIT
- 英文名称：PBIT
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10438
- cas：2514-30-9
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10438 |
| 用途 | 科研检测 |
| 英文名称 | PBIT |
| 包装规格 | 1MG |
| CAS编号 | 2514-30-9 |
| 别名 | PBIT |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C14H11NOS
分子量:241.31
溶剂:DMSO (24 mg/ml) ethanol (5 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):JARID1 lysine demethylase inhibitor
Function / Pharmacology:The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.
分子式:C14H11NOS
分子量:241.31
溶剂:DMSO (24 mg/ml) ethanol (5 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):JARID1 lysine demethylase inhibitor
Function / Pharmacology:The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.
