纯度:98% by TLC,;NMR (Conforms)
分子式:C17H13N3O2
分子量:291.3
溶剂:DMSO (45 mg/ml) DMF (30 mg/ml) Ethanol (10 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):KDM5B histone demethylase inhibitor
Function / Pharmacology:AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1