纯度:98% by TLC,;NMR (Conforms)
分子式:C20H8O4S
分子量:344.34
溶剂:DMSO (15 mg/ml) DMF (15 mg/ml)
性状:Orange solid
存储:-20°C
Activity (short version):Autophagy inducer
Function / Pharmacology:A new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin as determined using an immunoaffinity approach.1