纯度:98% by TLC,;NMR (Conforms)
分子式:C19H22N4S ? HCl
分子量:374.93
溶剂:DMSO (up to 25 mg/ml) or in Water (up to 45 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Fatty acid synthase inhibitor
Function / Pharmacology:Potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1 IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 μM in an isolated enzyme assay. Displays potent antitumor activity in the MMTV-Neu HER2+ breast cancer model.1 Reduces HIV-1 virion production by 90% (EC50=213 nM).2