纯度:97% by HPLC;NMR (Conforms)
分子式:C25H42O6
分子量:438.60
溶剂:DMSO or ethanol
性状:White solid
存储:-20°C
Activity (short version):Spliceosome inhibitor
Function / Pharmacology:A novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit SF3b.2 Specifically targets SAP155, a subunit of SF3b responsible for pre-mRNA splicing.3 Displays anti-angiogenic activity via down-regulation of VEGFR-2 and HIF-1α.4 Spliceosome inhibitors have attracted enormous attention due to their potential use in cancer treatment.5