|
RI-1
- 英文名称：RI-1
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10456
- cas：415713-60-9
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10456 |
| 用途 | 科研检测 |
| 英文名称 | RI-1 |
| 包装规格 | 1MG |
| CAS编号 | 415713-60-9 |
| 别名 | RI-1 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C14H11Cl3N2O3
分子量:361.61
溶剂:DMSO (45 mg/ml) Ethanol (10 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):RAD51 inhibitor
Function / Pharmacology:RI-1 is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.
分子式:C14H11Cl3N2O3
分子量:361.61
溶剂:DMSO (45 mg/ml) Ethanol (10 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):RAD51 inhibitor
Function / Pharmacology:RI-1 is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.
