纯度:98% by TLC,;NMR (Conforms)
分子式:C17H13ClN4
分子量:308.76
溶剂:DMSO (30 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):pan-JUMONJI histone demethylase inhibitor
Function / Pharmacology:A novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model.1 Suppresses translation initiation and enhances mTOR inhibitor sensitivity.2 Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.3