纯度:98% by TLC,;NMR (Conforms)
分子式:C10H4Cl4O2
分子量:297.95
溶剂:DMSO (30 mg/ml) Ethanol (6 mg/ml)
性状:Yellow solid
存储:RT
Activity (short version):Adenylate cyclase 1 inhibitor, analgesic activity
Function / Pharmacology:A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1 Displays analgesic properties in a mouse model of inflammatory pain.1