纯度:98% by TLC NMR conforms
分子式:C16H29NO
分子量:251.41
溶剂:DMSO (up to 25 mg/ml) on in Ethanol (up to 25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Novel cannabinoid CB2 agonist; antiinflammatory
Function / Pharmacology:Analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human monocytes/macrophages via the CB2 receptor.1 Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively)2. It elevates intracellular Ca2+ levels in CB2-positive but not in CB2-negative cells and this effect was blocked by SR144528.2 It significantly inhibits LPS-induced TNFα and IL-1β expression in a CB2-independent manner.2