纯度:98% by HPLC/TLC;NMR (Conforms)
分子式:C23H29Cl2N3O
分子量:434.40
溶剂:DMSO (30 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):NEDD8 ligation inhibitor
Function / Pharmacology:A potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1 It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex.2 NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.1