纯度:98% by HPLC;NMR (Conforms)
分子式:C20H22N10O13P2·2Na
分子量:718.38
溶剂:DMSO (>25 mg/ml) Water (10 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Endogenous STING agonist
Function / Pharmacology:2',3'-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist.1 Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor.2,3 Induces autophagy which is a mechanism for clearance of DNA and viruses in the cytosol.4 DNA damage stimulates 2’,3’-cGAMP which stimulates an inflammatory response.5