纯度:98% by TLC;NMR (Conforms)
分子式:C24H21F2NO3
分子量:409.43
溶剂:DMSO (25 mg/ml) Ethanol (15 mg/ml)
性状:White or off-white solid
存储:RT
Activity (short version):Cholesterol absorption inhibitor
Function / Pharmacology:Inhibits cholesterol absorption in the intestine by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter.1 Undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1.2 Inhibits dengue virus infection in Huh-7 cells by blocking cholesterol transport.3 Ameliorates steatohepatitis by activation of autophagy and inhibition of NLRP3 inflammasome.4