纯度:98% by HPLC;NMR (Conforms)
分子式:C35H38N4O6·2HCl
分子量:683.63
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:RT
Activity (short version):Calcium channel blocker / SARS-CoV2 3CLpro inhibitor
Function / Pharmacology:Manidipine is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature. Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4