![]() |
DRB
- 英文名称:DRB
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10476
- cas:53-85-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10476 |
用途 | 科研检测 |
英文名称 | DRB |
包装规格 | 1MG |
CAS编号 | 53-85-0 |
别名 | DRB |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C12H12Cl2N2O4
分子量:319.14
溶剂:DMSO (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Transcription inhibitor, CK2 inhibitor
Function / Pharmacology:A classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 μM. 3 Suppresses the SIRT1/CK2α pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5
分子式:C12H12Cl2N2O4
分子量:319.14
溶剂:DMSO (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Transcription inhibitor, CK2 inhibitor
Function / Pharmacology:A classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 μM. 3 Suppresses the SIRT1/CK2α pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5