纯度:98% by HPLC;NMR (Conforms)
分子式:C12H12Cl2N2O4
分子量:319.14
溶剂:DMSO (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Transcription inhibitor, CK2 inhibitor
Function / Pharmacology:A classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 μM. 3 Suppresses the SIRT1/CK2α pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5