纯度:>98%
分子式:C34H49N5O6
分子量:623.78
溶剂:DMSO (1 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):HDAC inhibitor
Function / Pharmacology:Apicidin is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC’s).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression causing cell cycle arrest in the G1 phase.2 Apicidin dramatically decreases HIF-1α protein levels and transcriptional activity in human and mouse tumor cell lines.3