纯度:98% by TLC,;NMR (Conforms)
分子式:C20H34O4
分子量:338.48
溶剂:DMSO (10 mg/ml) Ethanol (1 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):DNA polymerase inhibitor
Function / Pharmacology:Aphidicolin specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases1. Arrests cell cycle at early S phase while allowing continued cell growth2. Potentiates apoptosis induction induced by other agents3. Increases gene amplification frequency in HeLa S3 cells overexpressing Bcl-24.