纯度:98% by HPLC;NMR (Conforms)
分子式:C29H37NO5
分子量:479.61
溶剂:DMSO (5 mg/ml) Ethanol (10 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Actin filament disrupting agent
Function / Pharmacology:A cell permeable fungal toxin which binds to the barbed end of actin, inhibiting its polymerization.1 Inhibits cell division, migration and glucose transport.2 Causes cell cycle arrest at G2/M and induces apoptosis in HCT-116 colorectal carcinoma cells.3 Cytochalasin B-induced membrane vesicles (CIMVs) retain cell surface receptors of the parent cells and retain fusion specificity with target cells.4 CIMVs are a promising new vector system for drug and biomolecule delivery due to their natural origin and participation in intercellular communication.5