纯度:98% by HPLC;NMR (Conforms)
分子式:C13H14N2O4S2
分子量:326.39
溶剂:DMSO (15 mg/ml)
性状:White lyophilized solid
存储:-20°C
Activity (short version):Immunomodulator
Function / Pharmacology:A fungal metabolite with immunosuppressive properties; blocks phagocytosis, cytokine production and proliferation of T and B cells.1 Inhibits chymotrypsin-like activity of 20S proteasome preventing IκBα degradation and preventing NF-κB degradation2. Displays antiinflammatory activity3 and blocks leukotriene B4 production via inhibition of LTA4 hydrolase4. It inhibits nuclear NOTCH2 and recovers a tumor-suppressor NOTCH3 activity in chronic lymphocytic leukemia cells.5