纯度:>98%
分子式:C21H39NO6
分子量:401.54
溶剂:DMSO (20 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Blocks sphingolipid biosynthesis
Function / Pharmacology:Myriocin is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.3