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Penitrem A
  • 英文名称:Penitrem A
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10516
  • cas:12627-35-9
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10516
用途 科研检测
英文名称 Penitrem A
包装规格 1MG
CAS编号 12627-35-9
别名 Penitrem A
纯度 98+%
分子式
是否进口
纯度:99% by HPLC;NMR (Conforms)
分子式:C37H44ClNO6
分子量:634.21
溶剂:DMSO (6 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):High conductance Calcium activated potassium channel inhibitor
Function / Pharmacology:Fungal mycotoxin. Selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+ (BK, KCa1.1) channel (100% block at 10 nM).1 Displays brain neurotoxicity in rats along with dose-dependent convulsions and death.2 An important tool for studying the role of BK channels in vascular function which is effective in cellular, tissue and in vivo experiments.3 Inhibits BK channels in inside-out and cell-attached patches, whereas iberiotoxin (considered the gold standard BK channel blocker) does not.3 May be used to partially ablate Purkinje cells in immature rat cerebellum providing a model for neural stem cell transplantation studies.4 CAUTION: Potent Toxin. Take proper precautions to prevent ingestion, inhalation and skin contact.
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