纯度:99% by HPLC,;NMR (Conforms)
分子式:C28H38O6
分子量:470.60
溶剂:DMSO (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):NFκB and angiogenesis inhibitor
Function / Pharmacology:Displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro (IC50 = 12 nM) and in vivo.1 Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2 Covalently binds to the intermediate filament protein, vimentin3 inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in in vivo models.5