纯度:>98% by HPLC,;NMR (Conforms)
分子式:C26H29Cl2N5O3
分子量:530.45
溶剂:DMSO (100 mg/ml); Ethanol (up to 25 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):Dual Src/Abl kinase inhibitor
Function / Pharmacology:An ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM).1 It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR.2 Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants.3 Enhances retinoic acid-induced differentiation of HL-60 leukemia cells.4 Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells).5