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Bosutinib
  • 英文名称:Bosutinib
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10535
  • cas:380843-75-4
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10535
用途 科研检测
英文名称 Bosutinib
包装规格 1MG
CAS编号 380843-75-4
别名 Bosutinib
纯度 98+%
分子式
是否进口
纯度:>98% by HPLC,;NMR (Conforms)
分子式:C26H29Cl2N5O3
分子量:530.45
溶剂:DMSO (100 mg/ml); Ethanol (up to 25 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):Dual Src/Abl kinase inhibitor
Function / Pharmacology:An ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM).1 It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR.2 Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants.3 Enhances retinoic acid-induced differentiation of HL-60 leukemia cells.4 Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells).5
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