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Bosutinib
- 英文名称:Bosutinib
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10535
- cas:380843-75-4
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10535 |
用途 | 科研检测 |
英文名称 | Bosutinib |
包装规格 | 1MG |
CAS编号 | 380843-75-4 |
别名 | Bosutinib |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC,;NMR (Conforms)
分子式:C26H29Cl2N5O3
分子量:530.45
溶剂:DMSO (100 mg/ml); Ethanol (up to 25 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):Dual Src/Abl kinase inhibitor
Function / Pharmacology:An ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM).1 It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR.2 Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants.3 Enhances retinoic acid-induced differentiation of HL-60 leukemia cells.4 Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells).5
分子式:C26H29Cl2N5O3
分子量:530.45
溶剂:DMSO (100 mg/ml); Ethanol (up to 25 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):Dual Src/Abl kinase inhibitor
Function / Pharmacology:An ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM).1 It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR.2 Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants.3 Enhances retinoic acid-induced differentiation of HL-60 leukemia cells.4 Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells).5