纯度:98% by TLC,;NMR (Conforms)
分子式:C21H20N4O3
分子量:376.42
溶剂:DMSO (25 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):HDAC inhibitor
Function / Pharmacology:Potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 > 100 μM).1 In vivo, MS-275 has been shown to inhibit tumor growth via induction of the tumor supressors p21WAF1/CIP1 and gelsolin2 and to block cell proliferation in a variety of cancer cell lines3,4. The compound has also shown significant anti-rheumatic activity in rat and mouse arthritis models.5