纯度:99% by HPLC,;NMR (Conforms)
分子式:C32H29N5O2
分子量:515.61
溶剂:DMSO (7 mg/ml)
性状:Orange solid
存储:-20°C
Activity (short version):PKC inhibitor
Function / Pharmacology:Potent and selective PKCβ inhibitor. IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell lines via inhibition of the AKT signaling pathway.2 Induces mitotic missegregation and preferential cytotoxicity in colorectal cancer cells with chromosomal instability.3 Attenuates ampheta-mine-stimulated dopamine efflux.4 Inhibits blood-brain barrier leakiness in a mouse model.5