纯度:98% by TLC;NMR (Conforms)
分子式:C20H20BrN3O2S·2HCl
分子量:519.28
溶剂:DMSO (50 mg/ml) Water (10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):PKA inhibitor
Function / Pharmacology:H-89 is a commonly used inhibitor of protein kinase A (PKA IC50 = 140 nM). Inhibits a variety of other kinases including S6K1 (IC50 = 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 μM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 μM).1,2