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Irinotecan HCl
  • 英文名称:Irinotecan HCl
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10556
  • cas:136572-09-3
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-16
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10556
用途 科研检测
英文名称 Irinotecan HCl
包装规格 1MG
CAS编号 136572-09-3
别名 Irinotecan HCl
纯度 98+%
分子式
是否进口
纯度:98% by TLC,;NMR (Conforms)
分子式:C33H38N4O6 ? HCl ? 3H20
分子量:586.69 ? 36.46 ? 54.05
溶剂:DMSO (50 mg/ml) Ethanol (4 mg/ml) Water (4 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Topoisomerase I inhibitor
Function / Pharmacology:Irinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
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