纯度:98% by TLC,;NMR (Conforms)
分子式:C33H38N4O6 ? HCl ? 3H20
分子量:586.69 ? 36.46 ? 54.05
溶剂:DMSO (50 mg/ml) Ethanol (4 mg/ml) Water (4 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Topoisomerase I inhibitor
Function / Pharmacology:Irinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3