纯度:98% by TLC,;NMR (Conforms)
分子式:C13H13N3O3
分子量:259.26
溶剂:DMSO (30 mg/ml)
性状:White solid
存储:RT
Activity (short version):Immunomodulator
Function / Pharmacology:Thalidomide analog which, like thalidomide,1 binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation2. Selective inhibition of IKZF1 and IKZF3 in multiple myeloma cells results in cell death3,4. Cell permeable. Caution: Teratogenic