纯度:98% by TLC,;NMR (Conforms)
分子式:C24H23FN4O3
分子量:434.47
溶剂:DMSO (33 mg/ml) Ethanol (1.7 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):PARP1 inhibitor
Function / Pharmacology:A highly potent and selective PARP-inhibitor with IC?? values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively.1 In a genetically engineered mouse model for BRCA1-associated breast cancer olaparib inhibited tumor growth and improved survival with no signs of toxicity.2 Synergizes with many other anticancer agents.3 Shows efficacy in colorectal cancers.4 Prevents house dust mite allergen-induced asthma in a mouse model.5