纯度:>98% by HPLC;NMR (Conforms)
分子式:C21H23N7O2S
分子量:437.52
溶剂:DMSO (16 mg/ml)
性状:White to off-white solid
存储:-20°C
Activity (short version):Multi-receptor tyrosine kinase inhibitor
Function / Pharmacology:Inhibits multiple receptor tyrosine kinases including VEGFR1,2 and 3 (IC50s=10, 30, 47 nM respectively) and PDGFRα, β and c-Kit (IC50s=71, 84, 74 nM respectively) and others such as FGFR.1 The drug targets both the tumor and endothelial cells in a mouse xenograft model of human multiple myeloma.2 It reduces joint pain and inhibits cartilage degeneration in rodent osteoarthritis models.3 VEGF inhibitors such as pazopanib have potential for treatment of neovascular age-related macular degeneration.4 In clinical use for renal cell carcinoma.5