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Pemetrexed
- 英文名称:Pemetrexed
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10569
- cas:357166-29-1
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10569 |
用途 | 科研检测 |
英文名称 | Pemetrexed |
包装规格 | 1MG |
CAS编号 | 357166-29-1 |
别名 | Pemetrexed |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC and HPLC,;NMR (Conforms)
分子式:C20H19N5O6 ? 2Na ? 7H2O
分子量:597.49
溶剂:Water (100 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Antifolate; antitumor agent
Function / Pharmacology:Pemetrexed is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM).1 A clinically useful anticancer agent.2 Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas.3 Activation of AMPK is associated with pemetrexed resistance.4 Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.5
分子式:C20H19N5O6 ? 2Na ? 7H2O
分子量:597.49
溶剂:Water (100 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Antifolate; antitumor agent
Function / Pharmacology:Pemetrexed is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM).1 A clinically useful anticancer agent.2 Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas.3 Activation of AMPK is associated with pemetrexed resistance.4 Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.5