纯度:98% by TLC [10% CH3OH in CH2Cl2, Rf = 0.25];NMR (Conforms)
分子式:C20H14N3OF
分子量:331.35
溶剂:DMSO (30 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):p38 MAP kinase inhibitor
Function / Pharmacology:Potent and selective p38 MAP kinase inhibitor acting at the ATP site1. Selectively inhibits the p38α and β isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively)2. Effectively blocks LPS-induced gene expression in monocytes3. Induces apoptosis4. Cell permeable.