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Sorafenib (base)
- 英文名称:Sorafenib (base)
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10575
- cas:284461-73-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10575 |
用途 | 科研检测 |
英文名称 | Sorafenib (base) |
包装规格 | 1MG |
CAS编号 | 284461-73-0 |
别名 | Sorafenib (base) |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:99% by TLC,;NMR (Conforms)
分子式:C21H16ClF3N4O3
分子量:464.83
溶剂:DMSO (200 mg/ml) Ethanol (3 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Raf-1 inhibitor (and other kinases)
Function / Pharmacology:Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-β (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM)1. Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms2. Inhibits activation of MAPK pathway and ERK phosphorylation3. Induces caspase-independent apoptosis in melanoma cells4. Clinically useful anticancer agent.
分子式:C21H16ClF3N4O3
分子量:464.83
溶剂:DMSO (200 mg/ml) Ethanol (3 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Raf-1 inhibitor (and other kinases)
Function / Pharmacology:Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-β (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM)1. Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms2. Inhibits activation of MAPK pathway and ERK phosphorylation3. Induces caspase-independent apoptosis in melanoma cells4. Clinically useful anticancer agent.