纯度:98% by HPLC;NMR (Conforms)
分子式:C19H12F4N4O2
分子量:404.32
溶剂:DMSO (40 mg/ml) Ethanol (2 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):p38α MAP kinase inhibitor
Function / Pharmacology:A potent and selective inhibitor of p38 MAP kinases, p38? MAPK and p38? (KD = 3.7 and 17 nM respectively).1 Inhibits IL-6, IL-1? and TNF? production in LPS-primed blood.1 Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 ?M.2 Provides only modest clinical efficacy in rheumatoid arthritis.3,4 Delays platelet lesions and leads to better maintenance of stored platelets.5