纯度:98% by TLC,;NMR (Conforms)
分子式:C20H15ClN4 2HCl
分子量:419.73
溶剂:DMSO (20 mg/ml) Water (100 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):VEGFRK inhibitor
Function / Pharmacology:Potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM)1. Weaker inhibitor of other tyrosine kinases including PDGFR-β (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 μM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 μM). Inhibits the growth of multiple myeloma cells in the bone marrow microenvironment2.